Autoimmune Diseases

Cullinan Therapeutics will present preclinical data on CLN-978, a CD19xCD3 bispecific T cell engager, at ACR Convergence 2025. Studies show CLN-978 rapidly depleted B cells in samples from RA, Sjögren’s, and SLE patients, and in nonhuman primates after subcutaneous dosing. In a SLE mouse model, it reduced B cells, anti-dsDNA IgG, and kidney IgG deposition. Cullinan is advancing CLN-978 in OUTRACE clinical programs for RA, SjD, and SLE.

Viridian Therapeutics (VRDN) announced the pricing of its public offering of 11,425,000 shares at $22.00 each, potentially generating $251.35 million in gross proceeds. Underwriters have an option to purchase additional shares. Closing is expected around October 23, 2025. Viridian will use the funds to support commercialization of veligrotug and VRDN-003 for Thyroid Eye Disease, ongoing research and development, and general corporate purposes. Jefferies, Leerink Partners, Evercore ISI, and Stifel are managing the offering.

Dianthus Therapeutics (DNTH) will report topline results from its Phase 2 MaGic trial of claseprubart (DNTH103) in generalized Myasthenia Gravis (gMG) on September 8, 2025, at 8:00 a.m. EDT. The clinical-stage biotech company, focused on antibody complement therapeutics for autoimmune diseases, will host a conference call and webcast with a Q&A session. Investors can access the webcast via the company’s investor relations website, with a replay available afterward. Claseprubart targets the classical complement pathway, potentially offering a targeted gMG treatment.

Aurinia Pharmaceuticals will present Phase 1 study results for its investigational therapy AUR200 on June 30, 2025. The company, focused on autoimmune diseases, previously launched LUPKYNIS and is developing AUR200 as a dual inhibitor targeting BAFF and APRIL. The findings will be shared via webcast and conference call.

BioNxt Solutions has secured a pivotal European patent for its sublingual drug delivery platform, enhancing its intellectual property position for treating autoimmune diseases. The technology underpins BNT23001, a fast-dissolving oral film of Cladribine aimed at revolutionizing multiple sclerosis therapy by replacing injections with a needle-free, bioavailable alternative. Global patent filings are advancing in the U.S., Japan, and Eurasia, targeting a $150B+ autoimmune market. Upcoming bioequivalence studies in 2025 could enable accelerated EU approval. The platform also shows potential for lupus and arthritis treatments, with preclinical data suggesting improved delivery of biologic agents, positioning BioNxt as a leader in precision drug reformulation.

GRI Bio (NASDAQ: GRI), a San Diego-based biotech targeting iNKT cells for autoimmune therapies, will present its immunomodulatory platform at A.G.P.’s 2025 Healthcare Showcase on May 21 (2:40 PM ET) via live webcast. Dr. Marc Hertz, CEO, will outline advancements over traditional CAR-T approaches and highlight upcoming Phase II results for GRI-0621 (IPF/lupus pipelines) and its 500-compound library. The event attracts 500+ investors and historically correlates with 8% stock performance gains, offering critical visibility for the company’s early-inflammation intervention strategy. [99 words]