HFpEF

BioAge Labs presents preclinical data demonstrating apelin receptor (APJ) agonist potential for diabetic obesity and heart failure with preserved ejection fraction (HFpEF). APJ activation, acting as an exercise mimetic, enhances the effects of incretin therapy, improving glycemic control and offering cardioprotective benefits. The company is developing next-generation APJ agonists, including oral and injectable formulations, with an IND filing planned for 2026, aiming to develop new therapies for obesity and its complications.