HG-CT-1

Hemogenyx Pharmaceuticals secured £620,000 through convertible loan notes (CLNs) to fund the clinical trial of HG-CT-1, a CAR-T cell therapy. Issued at £5.30 per share, the non-interest bearing CLNs will automatically convert into 116,982 Ordinary Shares around November 15, 2025, following eased headroom restrictions under FCA Prospectus Rules. The funding supports the ongoing Phase I trial for relapsed or refractory acute myeloid leukemia. The new shares will be admitted to trading on the London Stock Exchange.

Hemogenyx Pharmaceuticals (LSE:HEMO, OTC:HOPHF) has successfully treated the third patient in its Phase I clinical trial of HG-CT-1, a CAR-T cell therapy for relapsed/refractory acute myeloid leukemia (R/R AML), completing the first adult dose cohort. The FDA granted special permission for the treatment. The first two patients remain alive at six and three months post-treatment. Hemogenyx plans to initiate a second adult dose cohort and a pediatric trial arm, evaluating safety and anti-leukemic activity.