mazdutide

Innovent Biologics will present at the ADA’s 85th Scientific Sessions, unveiling research on its pipeline for metabolic disease. Key highlights include IBI3030, a novel anti-PCSK9 antibody conjugate, and promising results on mazdutide, a dual GCG/GLP-1 receptor agonist. Mazdutide data will focus on liver fat reduction, MASH and fibrosis improvement, and uric acid reduction. The presentation will feature results from preclinical studies and investigator-initiated trials, pointing to Innovent’s focus on innovative metabolic disease therapies.

Innovent Biologics initiated a Phase 3 trial (GLORY-OSA) in China for mazdutide, a dual GCG and GLP-1 receptor agonist. The study will evaluate the drug’s efficacy and safety in Chinese patients with obesity and moderate-to-severe obstructive sleep apnea (OSA). Mazdutide has shown potential in weight loss and metabolic improvements, representing a potential treatment for a condition that affects millions in China, where current diagnosis rates are low. This marks the seventh Phase 3 study for the drug.

Innovent Biologics’ dual GCG/GLP-1 agonist mazdutide demonstrated significant weight loss (14.84% vs. 0.47% placebo) in a Phase 3 trial (GLORY-1) with 610 Chinese adults with obesity over 48 weeks, published in *NEJM*. Over 50% achieved ≥15% weight reduction, alongside improved cardiovascular and liver health. Safety aligned with GLP-1 therapies, with transient gastrointestinal effects. This marks the first NEJM-published metabolic therapy trial from China, signaling the nation’s rise in drug innovation. Experts emphasized mazdutide’s potential in addressing China’s obesity crisis under “Healthy China 2030.” Partnerships with Eli Lilly and ongoing trials aim to expand its use in metabolic diseases.