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At ESMO 2025, Kura Oncology presented early data on farnesyl transferase inhibitors (FTIs) darlifarnib and tipifarnib. Darlifarnib monotherapy showed on-target activity in HRAS-mutant tumors. Darlifarnib combined with cabozantinib yielded a 33-50% ORR in renal cell carcinoma. Tipifarnib with alpelisib achieved a 47% ORR in heavily pretreated PIK3CA-altered head and neck cancer. These preliminary results suggest FTIs can enhance targeted therapies by addressing resistance mechanisms. Further studies are ongoing to determine optimal dosing and durability.

Roche’s Phase III evERA trial showed promising results for giredestrant plus everolimus in ER-positive, HER2-negative advanced breast cancer after CDK4/6 inhibitor therapy. The combination significantly improved progression-free survival (PFS) compared to standard endocrine therapy plus everolimus. The PFS risk reduction was 44% in ITT and 62% in ESR1-mutated patients. While overall survival data is still maturing, a positive trend was observed. Giredestrant + everolimus could become a new standard of care.

Light & Wonder faces a setback in its legal battle with Aristocrat as a Nevada court granted Aristocrat’s motion for discovery of Light & Wonder’s “hold and spin” game math models released since 2021. Aristocrat alleges Light & Wonder may have incorporated its proprietary algorithms. Light & Wonder maintains confidence that no Aristocrat math was used beyond previously identified games. The outcome of the litigation, with discovery concluding in 2025 and 2026, could significantly impact game development and intellectual property rights within the gaming industry.

Kolibri Global Energy Inc. (KEI, KGEI) urges shareholders to vote against a proposed resolution capping common shares at 37,367,894 during a special meeting initiated by TFG Asset Management UK LLP. While initially all officers and directors opposed the resolution, Director Neuhauser is now undecided. The board unanimously recommends rejecting the proposal, citing impeded fiduciary duty, existing safeguards, competitive threats, limited flexibility, and increased costs. They believe the cap would negatively impact shareholder value and the company’s growth potential. The proxy voting deadline is November 21, 2025.

On October 17, 2025, Signature Resources (OTCQB: SGGTF; TSXV: SGU) granted 2,400,000 incentive stock options to its board, management, and advisors. The options have an exercise price of $0.055, aligning with the concurrent financing price, and expire in five years. Vesting is 25% immediately, followed by 25% annually until the third anniversary. These options serve as the sole compensation for non-executive directors and are subject to the company’s Option Plan and regulatory approvals.

Four Corners Property Trust (FCPT) acquired a Heartland Dental property in Oklahoma for $3.3 million at a 6.9% cap rate. The property, located on a high-traffic corridor, is under a corporate-backed triple-net lease with four years remaining and a near-term rent increase. This acquisition reflects FCPT’s focus on stable, income-generating assets with strong tenants in resilient sectors like healthcare. FCPT, a REIT specializing in net-leased restaurant and retail properties, aims to expand its portfolio through strategic acquisitions.

Silver X Mining Corp. released a Preliminary Economic Assessment (PEA) for its Nueva Recuperada project, targeting 6.2 million ounces of silver equivalent annually over a 14-year mine life. The PEA outlines a $439 million after-tax NPV (5% discount) and a 3-year payback, with an initial CapEx of $82 million. Production is planned across two mills at 3,000 tpd. The study relies on inferred resources, carrying inherent risks, and production decisions are not based on proven reserves or a feasibility study.

UPAY (UPYY) announced its South African subsidiary, ACPAS, will sponsor the MicroFinance South Africa (MFSA) Annual General Meeting and Conference on October 22, 2025, where MFSA will rebrand as CASA (Credit Association of South Africa). ACPAS will be a Legacy Partner, highlighting its commitment to supporting South Africa’s microfinance and credit sectors through technology and compliance. UPAY aims to capitalize on the rebranding by aligning with CASA’s expanded scope to drive financial inclusion.

blueharbor bank (BLHK) reported strong Q3 2025 earnings, driven by loan growth and efficient operations. ROA reached 2.08% and ROE 18.54%. Diluted EPS surged 51% to $0.95, and the net interest margin expanded to 4.46%. Loan and deposit growth were robust, up 20% and 17% annualized, respectively. The efficiency ratio was an impressive 37.76%. Total assets increased to $571.8 million, with zero non-performing assets, and solid capital ratios exceeding regulatory requirements. Net income was $2,852,118, a significant rise compared to Q3 2024.

EPWK (EPWK), a NASDAQ-listed creative design firm, will launch “EPWK Curated Goods,” an e-commerce platform for curated physical products catering to Chinese and English speakers, within three months. Targeting “Urban Life Explorers” aged 25-40, the platform focuses on products with emotional and aesthetic appeal, aligning with the “Neo-Pragmatism” consumer trend. Emphasizing “Good-looking, Good-to-use, and Good-surprise,” the platform aims to be a “Lifestyle Curator,” offering products that enhance daily life and express identity. EPWK leverages its creative ecosystem to drive innovation and global brand expansion. The existing platform has over 25 million registered users and facilitated $1.67 billion in GMV.