Markets

Alnylam Pharmaceuticals’ AMVUTTRA (vutrisiran) showed sustained benefits in transthyretin-mediated amyloidosis cardiomyopathy (ATTR-CM) patients in the HELIOS-B Phase 3 study. Data presented at ESC Congress 2025 revealed that vutrisiran reduced the risk of all-cause mortality or first cardiovascular event by 37% in the overall population and 42% in the monotherapy group over 48 months. The open-label extension maintained improvements in quality of life and cardiac biomarkers, supporting vutrisiran as a potential first-line ATTR-CM therapy.

Huawei Chairman Guo Ping addressed new hires in July 2025, discussing the company’s strengths and weaknesses in a “decoupling world.” Acknowledging restricted access to advanced technologies, Guo emphasized Huawei’s strong domestic base and ambition to become a global leader in ICT and smart devices. He highlighted strategies like “hardware-software synergy” and “non-Moore’s Law approaches” to overcome limitations and offer “another option” to the world. Guo urged new employees to seize opportunities in the dynamic industry and contribute to reshaping it.

Santana Equestrian Private Financial (SEQP) is defending its manure recycling operations against an environmental petition filed with the Florida DEP (Case No. 25-1566). SEQP filed a Motion to Dismiss, citing protection under Florida’s House Bill 211 and the Right to Farm Act. The company manages 612,000 pounds of manure daily and implemented a “Delivery Services Partner Program” to service over 400 farms. While confident, SEQP acknowledges potential reputational and operational risks.

JD.com founder Richard Liu made a surprise appearance at a Jiangsu Provincial City Football League match in Suqian, cheering on the local team. This follows JD.com’s recent sponsorship of the league and coincides with the opening of four JD Discount Supermarkets in Suqian. Liu was also seen mingling with locals, highlighting his commitment to the region. The events showcase JD.com’s strategy of intertwining community engagement with business expansion, demonstrating investment in local sports development and economic opportunities.

Gold Reserve Ltd. announced the U.S. Government’s Statement of Interest in the New York federal court litigation regarding the validity of 2020 PDVSA bonds. The U.S. supports the 2015 National Assembly of Venezuela’s claim that the bonds, issued by the Maduro regime, are invalid under Venezuelan law and urges the court to consider the Assembly’s views. While taking no position on pending summary judgment motions, the U.S. affirmed recognition and support for the 2015 National Assembly as the government of Venezuela. Investors are cautioned to review Gold Reserve’s filings for risk factors.

A Chinese restaurant owner faces potential legal issues for posting surveillance video of a customer using 40 napkins in 5 minutes. Legal experts suggest sharing the unedited video may violate the customer’s privacy and portrait rights. Unauthorized filming and online sharing infringe upon these rights, allowing victims to demand content removal and cessation of the behavior. The incident highlights the need for content creators to be aware of privacy laws and obtain explicit consent when filming others to avoid legal challenges.

A recent court ruling in China has forced an insurer to pay a claim under mandatory traffic accident liability insurance despite the policy’s “midnight start” clause, because the insurer failed to offer alternatives or explain the risks of the clause. The court deemed the clause invalid in this specific case, setting a potential precedent. However, the claim under commercial third-party liability insurance was rejected, as the driver was deemed to have implicitly accepted the terms. The insurer was ordered to pay 180,000 yuan.

Genentech and Alnylam plan to initiate a Phase III trial for zilebesiran, an RNAi therapeutic for hypertension, informed by positive Phase II KARDIA program data. The KARDIA-3 study showed zilebesiran achieved clinically meaningful reductions in systolic blood pressure at month three, sustained through month six, with encouraging safety. The ZENITH Phase III trial will enroll approximately 11,000 patients with uncontrolled hypertension to evaluate zilebesiran’s impact on cardiovascular outcomes. Zilebesiran offers twice-yearly dosing and targets a key regulator of blood pressure.

Amarin Corporation presented REDUCE-IT® trial sub-analyses at ESC Congress 2025, highlighting the benefits of VASCEPA®/VAZKEPA® (icosapent ethyl) regarding cardiovascular risk reduction. Key findings include a 9% drop in total hospitalizations and a 44% relative risk reduction in cardiovascular events for patients with Cardiovascular-Kidney-Metabolic (CKM) syndrome. The treatment also showed significant MACE reductions across all ApoB quartiles. The ESC/EAS guidelines reaffirmed icosapent ethyl as a Class IIA therapy.

Jiangsu Provincial City Football League (“Su Chao”) is experiencing a surge in popularity, fueled by the online frenzy and innovative marketing. A cinematic trailer for the upcoming Nanjing vs. Xuzhou match went viral, highlighting the league’s competitive spirit. Alipay sponsors the Xuzhou team, incentivizing goals with consumption vouchers, driving a 19.5% increase in “Alipay Touch and Pay” usage after a previous match. Su Chao exemplifies community-driven sports and offers a compelling case study for brand engagement.