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10/23/2025 – 02:10 PM
CARLSBAD, Calif. – Ionis Pharmaceuticals (IONS), a prominent player in RNA-targeted therapeutics, has been recognized as a top employer in Science magazine’s annual survey of the biopharmaceutical sector. Securing the second-place ranking in its debut year, Ionis distinguished itself through robust scores in innovation, alignment of corporate and employee values, employee loyalty, and a culture of respect.
This accolade arrives as Ionis continues to make significant strides in the competitive landscape of RNA therapeutics. The company’s core technology revolves around antisense oligonucleotides (ASOs), designed to selectively modulate gene expression, a departure from traditional small molecule or antibody-based approaches. This precision at the genetic level offers potential for treating diseases with high unmet needs, particularly in neurology and cardiometabolic disorders.
“Our people are our greatest strength at Ionis,” stated Brett P. Monia, Ph.D., CEO of Ionis, highlighting the importance of talent to the company’s success. “Being featured as a top employer reflects both the caliber of our science and the unique spirit of the Ionis culture. Our team’s hard work enables breakthroughs that transform the lives of people living with serious diseases.”
The Science and Science Careers’ Top Employers Survey, based on nearly 5,500 responses from readers and invitees, evaluated companies across 24 criteria.
Eric Swayze, Ph.D., executive vice president, research at Ionis, emphasized the company’s patient-centric approach: “The work we do is challenging, but we are driven by a passion to help patients who are depending on us. This imperative focuses us, and together, we deliver bold and groundbreaking science that translates to better medicines.”
Ionis’s recognition as a top employer coincides with a period of increased investor and industry attention on RNA-based therapies. While the field holds immense promise, challenges remain in delivery, specificity, and potential off-target effects. Ionis’s advancements in chemistry and oligonucleotide design are critical in addressing these hurdles and expanding the therapeutic window for its ASO drugs.
The company’s pipeline includes treatments for neurological disorders like spinal muscular atrophy (SMA) and Huntington’s disease, as well as therapies targeting cardiovascular conditions. The success of Spinraza (nusinersen), an Ionis-developed drug for SMA, has validated the company’s RNA-targeting approach and paved the way for further innovation.
However, the competitive landscape is intensifying, with companies like Alnylam Pharmaceuticals and Dicerna Pharmaceuticals also developing RNAi-based therapies. Ionis will need to continue to innovate and demonstrate clinical efficacy to maintain its leadership position in the RNA therapeutics market. Its ability to attract and retain top talent, as reflected in the *Science* survey, will be a crucial factor in its future success.
About Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals is a biopharmaceutical company focused on discovering and developing RNA-targeted therapeutics to treat diseases with high unmet medical needs. As a pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies.
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