Structure Therapeutics (NASDAQ: GPCR) will release topline data from its ACCESS clinical program of alenigilprion, a once‑daily oral small‑molecule GLP‑1 receptor agonist for obesity, before market open on Monday, December 8, 2025. Management will host a conference call and webcast at 8:30 a.m. ET to discuss the results.
Investors can join the live webcast on the company’s Investor Relations events page; a replay will be posted roughly two hours after the live event and will remain available for 90 days.
Key Figures
Top‑line data date
December 8, 2025
ACCESS alenigilprion readout before market open
Conference call time
8:30 a.m. ET
Management discussion of ACCESS data
Webcast replay length
90 days
Replay on investor‑relations site
Market Reality Check
$34.56
Last Close
Volume
Volume 1,170,208 is at 0.92× the 20‑day average of 1,270,968, indicating typical activity ahead of the event.
Technical
Shares at $34.56 trade above the 200‑day moving average of $23.48 and 14.22 % below the 52‑week high of $40.29.
Peers on Argus
GPCR rose 5.21 % while nearby stocks showed modest moves (e.g., ELVN +1.77 %, NUVB +2.64 %, PGEN –5.01 %). The outperformance appears tied specifically to the pending ACCESS data release rather than a broader sector shift.
Historical Context
| Date | Event | Sentiment | Move | Catalyst |
|---|---|---|---|---|
| Nov 06 | Earnings update | Positive | +3.9 % | Reaffirmed ACCESS timing and disclosed strong cash balance through 2027. |
| Sep 02 | Investor conferences | Positive | +4.0 % | Announced participation in major healthcare investor forums. |
| Aug 06 | Earnings update | Negative | -0.7 % | Higher R&D spend and larger net loss amid oral obesity pipeline progression. |
| Jun 20 | Clinical data | Positive | +1.7 % | Preclinical data for oral amylin agonist and GLP‑1 candidate presented at ADA meeting. |
Recent earnings, conference and clinical updates have moved the share price in line with the tone of each announcement, showing no significant divergence.
The upcoming ACCESS readout follows a series of catalyst‑driven updates. In August and November 2025 earnings releases, Structure disclosed cash balances of $786.5 M and $799.0 M and reaffirmed a year‑end topline data target. A June 2025 clinical briefing highlighted promising preclinical signals for two oral candidates, while a September 2025 conference notice underscored expanding investor outreach. The December 8, 2025 announcement continues this disciplined cadence.
Regulatory & Risk Context
The company holds an effective S‑3ASR shelf registration dated August 6, 2025, expiring August 6, 2028, with no utilization recorded to date. This provides flexibility for future capital raises.
Market Pulse Summary
Structure Therapeutics has set a firm timetable for the pivotal ACCESS topline data on alenigilprion, with results slated for release before the market opens on December 8, 2025 and a management discussion at 8:30 a.m. ET. The schedule aligns with prior guidance that highlighted robust cash reserves and a year‑end data readout. Investors will be watching how the data fit within the broader obesity‑treatment narrative and whether the results trigger additional financing or development milestones.
AI-generated analysis. Not financial advice.
SAN FRANCISCO, Dec. 7, 2025 – Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical‑stage biopharmaceutical company focused on oral small‑molecule therapies for metabolic disease, announced that topline results from its ACCESS trial of alenigilprion, a once‑daily oral GLP‑1 receptor agonist for obesity, will be released before market open on Monday, December 8, 2025. Management will discuss the data on a conference call and webcast at 8:30 a.m. ET.
Structure leverages a next‑generation structure‑based drug‑discovery platform to build a pipeline of proprietary oral GPCR‑targeted compounds. By pursuing small‑molecule modalities, the company aims to overcome the manufacturing and distribution constraints of injectable biologics, potentially expanding access to millions of patients with obesity worldwide.
FAQ
When will Structure Therapeutics release the ACCESS topline data?
Topline ACCESS results will be released before market open on December 8, 2025.
What time is the conference call and webcast?
Management will present the data at 8:30 a.m. ET on December 8, 2025.
How can investors access the live webcast?
The webcast will be available on Structure’s Investor Relations events page.
When will the replay be available and for how long?
The replay will be posted about two hours after the live event and will remain accessible for 90 days.
What is alenigilprion?
Alenigilprion is Structure’s once‑daily oral small‑molecule GLP‑1 receptor agonist under development for the treatment of obesity.
How do I obtain phone dial‑in details for the call?
Dial‑in information can be obtained from the same investor events page after registration.
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